Alzheimer Netherlands

Alzheimer Netherlands
Alzheimer Netherlands
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Dr. Minke Kooistra, team leader for subsidies and implementation of Alzheimer Nederland, emphasizes the importance of these research projects: ‘Dementia is a very complex disease that we do not yet fully understand. The disease therefore requires a broad view of the causes, which is why we support research on various topics. Important themes discussed are harmful protein accumulations, blood vessels, inflammatory reactions, diagnostics and the effects of lifestyle on the development of dementia.’

Research is necessary

There are approximately 300,000 people with dementia in the Netherlands and that number will continue to increase in the coming years. There is currently no solution for the disease and Alzheimer Nederland wants to change that. Kooistra: ‘These studies have the potential to provide important knowledge about dementia. If we better understand the diseases and processes in the brain, we can also start working on solutions. Ultimately, we hope that the knowledge from the research projects will contribute to solutions for the various forms of dementia.’

Research possible thanks to donors

Thanks to the support of our donors, Alzheimer Nederland can make these studies possible:

  • Sylvie Lesuis (University of Amsterdam): Shifting E/I balance to rescue engram activity in AD – Changes in brain cells during memory loss in Alzheimer’s
  • Gerhard Drenthen (Maastricht University Medical Center): Do cerebral tissue markers explain why lifestyle factors affect cognition? – Can specific brain abnormalities explain the relationship between lifestyle and cognition?
  • Jackie Poos (Erasmus MC University Medical Center): Virtual Reality Social Cognition Game for Preclinical Frontotemporal Dementia – improving and personalizing early diagnosis of FTD with VR technology
  • Daphne Naessens (Amsterdam UMC, location AMC): The role of sleep in brain clearance and prevention of Alzheimer’s disease
  • Elisabeth Vinke (Erasmus MC University Medical Center): Unraveling brain aging patterns predictive of AD or ADRD – Distinguishing normal aging in the brain from disease processes of dementia
  • Emma Gerrits (Karolinska Institutet): Reconstruction of the cellular events that drive the neuropathology of FTDGRN – Mapping changes in the brains of people with FTD
  • Assia Tiane (Maastricht University): A new view on the role of myelination and memory in Alzheimer’s – The role of the protective layer around nerve cells in the development of Alzheimer’s
  • Lynn van Olst (Northwestern University): CAA-related inflammation as a model for Aβ immunotherapy side effects – Investigating processes that hinder removal of harmful amyloid protein from the brain
  • Gijsje Snijders (Icahn School of Medicine Mount Sinai New York): Transcriptional responses of human microglia in relation to Alzheimer disease – Inflammatory response of immune cells in the brain in Alzheimer’s
  • Wiep Scheper (Amsterdam UMC): Proteostatic neuron to astrocyte signaling induced by tau pathology – Response of brain cells to the harmful tau protein
  • Marcel Verbeek (Radboud university medical center): Clinical correlates of cerebral Amyloid angiopathy subTypes (CAT) – Demonstrate predictors of accumulation of the amyloid protein in blood vessels of the brain
  • Jeroen Hoozemans (Amsterdam University Medical Centers, location VUmc): Tau pathology and microglia activation in the retina of AD and tauopathies
  • Ginny Farías (Utrecht University): Unraveling region-specific mechanisms of Abeta production in polarized neurons – Formation of harmful Alzheimer’s proteins in brain cells
  • Alle Meije Wink (Amsterdam University Medical Centre, location VUmc): Early Multi-layer Brain network model biomarkers of ALzheiMer’s disease – Changes in connections between brain areas in Alzheimer’s disease
  • Harmen Krugers (University of Amsterdam): Targeting microglial stress hormone receptors to mitigate AD pathology – The effect of stress early in life on the development of Alzheimer’s
  • Frank Wolters (Erasmus MC – University Medical Center Rotterdam): Unraveling the APOE-ε2 paradox in vascular cognitive impairment and Alzheimer’s – Effect of genetic variation in a specific gene on blood values ​​and brain health
  • Lize Jiskoot (Erasmus Medical Center): Harmonization and modeling longitudinal multicenter MRI in genetic FTD – Mapping disease processes in the brain in FTD in people with a genetic form
  • Stephanie Vos (Maastricht University): Unraveling choroid plexus functioning in Alzheimer’s disease: a CSF study – The role of the choroid plexus brain region in Alzheimer’s disease

The article is in Dutch

Tags: Alzheimer Netherlands

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